786 research outputs found

    A Comparison of Perfect Table Cryptanalytic Tradeoff Algorithms

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    The performances of three major time memory tradeoff algorithms were compared in a recent paper. The algorithms considered there were the classical Hellman tradeoff and the non-perfect table versions of the distinguished point method and the rainbow table method. This paper adds the perfect table versions of the distinguished point method and the rainbow table method to the list, so that all the major tradeoff algorithms may now be compared against each other. Even though there are existing claims as to the superiority of one tradeoff algorithm over another algorithm, the algorithm performance comparisons provided by the current work and the recent preceding paper are of more practical value. Comparisons that take both the cost of pre-computation and the efficiency of the online phase into account, at parameters that achieve a common success rate, can now be carried out with ease. Comparisons can be based on the expected execution complexities rather than the worst case complexities, and details such as the effects of false alarms and various storage optimization techniques need no longer be ignored. A significant portion of this paper is allocated to accurately analyzing the execution behavior of the perfect table distinguished point method. In particular, we obtain a closed-form formula for the average length of chains associated with a perfect distinguished point table

    Analysis of the Parallel Distinguished Point Tradeoff

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    Cryptanalytic time memory tradeoff algorithms are tools for quickly inverting one-way functions and many consider the rainbow table method to be the most efficient tradeoff algorithm. However, it was recently announced, mostly based on experiments, that the parallelization of the perfect distinguished point tradeoff algorithm brings about an algorithm that is 50\% more efficient than the perfect rainbow table method. Motivated by this claim, while noting that the massive pre-computation associated with any tradeoff algorithm makes the non-perfect forms of tradeoff algorithms more practical, we provide an accurate theoretic analysis of the parallel version of the non-perfect distinguished point tradeoff algorithm. Performance differences between different tradeoff algorithms are usually not very large, but even these small differences can be crucial in practice. So we take care not to ignore the side effects of false alarms in providing an online time complexity analysis of the parallel distinguished point tradeoff algorithm. Our complexity results are used to compare the parallel non-perfect distinguished point tradeoff against the non-perfect rainbow table method. The two algorithms are compared under identical success rate requirements and the pre-computation efforts are also taken into account. Contrary to our anticipation, we find that the rainbow table method is superior in typical situations, even though the parallelization did have a positive effect on the efficiency of the distinguished point tradeoff algorithm

    Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis

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    This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule

    Multiple Unilateral Zosteriform Connective Tissue Nevi on the Trunk

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    Connective tissue nevus is not a true tumor, but rather a hamartoma involving various components of connective tissue. It presents as a slow-growing, painless, flesh-colored, or pink nodule or plaque that is evident from childhood. While any region of the body may be affected, there is a predilection for the trunk and extremities. A 20-month-old girl presented with three ipsilateral confluent popular plaques with zosteriform distribution that had formed over the previous 17 months on the left chest and abdomen. The patient remained asymptomatic. Unlike all previously reported cases demonstrating a single lesion, we report a connective tissue nevi in a child who presented with multiple unilateral zosteriform lesions, an unusual pattern of distribution without evidence of tuberous sclerosis complex

    Erythropoietin Reduces Death and Neurodevelopmental Impairment in Neonatal Hypoxic-Ischemic Encephalopathy

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    Purpose Erythropoietin (EPO) is a promising neuroprotective drug. We investigated whether EPO has beneficial effects on neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy (HIE). Methods We retrospectively reviewed the data of 56 infants with HIE born at or after 35 weeks of gestation who were admitted to Inha University Hospital between 2012 and 2021. Patients were divided into two groups based on EPO use and compared. In the EPO group, patients were administered 1,000 U/kg of EPO on days 1, 2, 3, 5, and 7, starting within 24 hours after birth. The primary outcome was death or neurodevelopmental impairment (NDI) at the age of 12 months. Results EPO was administered to 38 infants, and 18 did not receive EPO. Only 37.5% of patients with HIE (21/56) and 60% of patients with moderate-to-severe HIE (21/35) received therapeutic hypothermia. Among all patients with HIE, death or NDI (21.1 % vs. 50.0%; odds ratio [OR], 0.09; 95% confidence interval [CI], 0.01 to 0.78; P=0.029) and brain injury on imaging (42.1% vs. 83.3%; OR, 0.16; 95% CI, 0.03 to 0.92; P=0.040) were significantly lower in the EPO group than in the control group. Among patients with moderate-to-severe HIE, brain injury on imaging (54.2% vs. 90.9%; OR, 0.04; 95% CI, 0.002 to 0.700; P=0.027) was significantly lower in the EPO group than in the control group. Conclusion EPO administration significantly reduced mortality and NDI in infants with HIE. EPO can be considered an adjunctive therapeutic agent for neonatal HIE

    The effect of fermented porcine placental extract on fatigue-related parameters in healthy adults: A double-blind, randomized, placebo-controlled trial

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    © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Fatigue is one of the major health conditions induced by excessive stress or abnormal immune function or defective antioxidant systems. Placental extract has been reported to have various effects such as immune modulation and cellular regeneration. Fermented porcine placenta (FPP) is a safe nontoxic material, which is highly valuable as a functional food. The aim of this study was to investigate the anti-fatigue effects of FPP supplementation compared with a placebo product. Methods: In this double-blind, parallel, randomized, and placebo-controlled trial 84 healthy males and females, aged between 30 and 60 years were randomized to 320 mg of FPP once daily or placebo. The main outcome measures included efficacy of fatigue-inducing treadmill exercise on physical fatigue and fatigue-related parameters based on the questionnaire administered. Results: The IL-1β mRNA expression and fatigue severity scale were changed significantly after 8 weeks of treatment with fermented porcine placenta compared with placebo (p \u3c 0.05). Cortisol levels were significantly improved in participants younger than 45 years following treatment with FPP compared with placebo. Furthermore, the lactate and myoglobin levels were improved significantly in participants with BMI ≥ 23 kg/m2 (p = 0.045 and p = 0.011, respectively) following treatment with FPP versus placebo. Conclusions: Our study showed that FPP supplementation significantly ameliorated fatigue-related parameters and subjective symptoms in healthy adults. Therefore, our results indicate that FPP supplementation induced anti-fatigue effect by regulating the inflammatory response
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